![]() ![]() ![]() She was unnerved at first, but she managed to get over it.Cassandra then found some townspeople that had regained their sanity thanks to a shining blue crystal. She then realized that he had taken her fragment of Soul Edge. Cassandra called him a coward, but he told her that he already had what he wanted. As he retreated, Raphael commented that she had the power to dispel evil, although she was not as powerful as the Holy Stone. The two fought, and in the end, Cassandra managed to deliver a blow on him. There, she encountered Raphael, who sensed the fragment of Soul Edge that she carried. ![]() She went back to the town that she visited from her previous journey. After receiving a new pair of weapons from Rothion, Cassandra went out to search and join her sister in this quest. Once there, she was informed by Rothion that Sophitia left to destroy Soul Edge on her own. Forced to flee the city after being surrounded by the corrupted city-folks, she travelled back to Greece to ask her brother-in-law, Rothion, to forge her new weapons. However, she discovered the sacred weapons she carried to have cracks all over. Trying to help the inhabitants, much like Sophitia did in her last trip, Cassandra tracked the core of the evil in a castle atop the mountains. Not wanting to see her sister take on another dangerous quest, especially now that she has a family, Cassandra stole the sacred sword and, sneaking out of her home, she took the task of destroying Soul Edge.Ĭassandra travelled towards the east, where she found a town covered in evil energy. After briefly passing out from exhaustion, she saw the metal fragment resonating with the holy "Omega Sword", the sword her sister used on her past journey. Angered by her sister's panicked reaction, Cassandra ran to the Eurydice Shrine, screaming at Hephaestus for endangering her sister on behalf of his ego. Then, four years after the events of Soulcalibur, Cassandra visits her and Sophitia's home, only to be greeted by the sight of Sophitia's two children fighting over a metal shard of Soul Edge that Sophitia's husband, Rothion, had found. So when Sophitia left again for a second time, Cassandra knew that she had gone out to destroy Soul Edge. Seven years ago, Cassandra witnessed Taki bringing back an unconscious Sophitia and pulling a fragment of Soul Edge out of her sister's body. ![]() She's also briefly mentioned on Sophitia's Soulcalibur profile as well, as she witnessed Taki bringing her unconscious sister home, and goes on a shopping trip when Sophitia meets her future husband, Rothion. Cassandra's nickname is The Valiant Princess, because she is strong hearted, determind and willing to save her family.Ĭassandra has been mentioned as early as Sophitia's Soul Edge profile, though her name was stated as "Kathandra". The younger sister of Soul Edge character Sophitia, Cassandra's main goal is to relieve her sister from the burden of the Soul Edge and the oracles of the blacksmith god Hephaestus. Cassandra made her debut in Soulcalibur II, and has returned in Soulcalibur III, Soulcalibur IV and Soulcalibur: Broken Destiny as a standard character for all four games. "Were you looking forward to winning? Oh, I'm sorry!"Ĭassandra, as she appears in Soulcalibur IV.Ĭassandra Alexandra ( カサンドラ・アレクサンドル, Kasandora Arekusandoru Greek: Κασσάνδρα Αλεξάνδρα) is a character in the' Soul series of fighting games. ![]()
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![]() ![]() It is estimated that the rate of symptomatic femoral head ON is 2–4.5 cases per patient year, resulting in 10,000–20,000 new cases annually in the United States. įemoral head osteonecrosis (ON) is a common disease and potentially disabling disorder affecting mainly middle-aged adults that can lead to early osteoarthritis due to femoral head collapse and joint incongruity. Because of the severe consequences of undiagnosed femoral neck stress fractures, the diagnosis is based on combined imaging findings of periosteal edema, endosteal edema, and high cortical signal, regardless of visible fracture line. With any of these findings, one should carefully evaluate for a hypointense band in the marrow or focal cortical abnormality, indicating stress fracture and necessitating prolonged non-weight-bearing or rest from sporting activity. Classic MRI features include ill-defined focal or diffuse high T2 bone marrow signal due to microtrabecular fractures and intramedullary edema, with or without corresponding low T1 signal and/or periosteal edema (Fig. Radiographs are not very sensitive in the identification of stress injuries of the femoral neck. This causes temporary weakening of the marrow and cortical bone, leading to microtrabecular fractures (stress reaction) and cortical failure (stress fracture). The repetitive overloading stimulates bone remodeling, beginning with osteoclastic activity that is not matched by reparative osteoblastic activity and periosteal maturation, which lag 10–14 and 20 days, respectively. Stress fractures are classified as fatigue, resulting from normal bone being subjected to abnormal repetitive forces, and insufficiency, due to normal stress placed on abnormal bone. Stress injuries are most commonly seen in endurance athletes, such as runners and military recruits, as well as recreational athletes with sudden increase in activity. However, because stress injuries may progress to complete fracture and result in prolonged recovery or career-ending complications, it is imperative to identify these injuries early. Stress injuries are due to a mismatch between native bone strength and chronic mechanical load applied on bone over time. Recently, high-resolution conventional MR imaging is replacing MR arthrography at many centers. If symptoms or clinical exam findings suggest intra-articular pathology, dedicated small field-of-view (FOV) MR arthrography of the hip is considered the imaging method of choice. ![]() For symptoms of generalized pain or nonspecific physical exam findings, imaging is best performed with conventional MRI of the pelvis and hip. According to the American College of Radiology Musculoskeletal Imaging Criteria, MRI is the next appropriate imaging method in those individuals with negative radiographs. Anteroposterior view of the pelvis is standard, and dedicated views of the symptomatic hip are often performed in the athletic hip which include cross-table lateral, frog-leg lateral, or Dunn lateral. The radiographic examination is a critical component in the diagnostic evaluation and treatment decision-making process and considered the first-line imaging technique in the evaluation of hip pain. ![]() ![]() But it should work with any guitars that pair via bluetooth and show up as a normal controller. You can also change what controller the adaptor emulates using button commands, but I couldn't be bothered to test it since DS4 mode works fine anyway. Then, all you need to do is remap the green and red buttons to the opposites (since the adaptor swaps them by default). However, I have an 8BitDo Wireless Receiver, and it works perfectly! Pairing is super simple (push the button on the adaptor, and the sync button on the WiiMote) and by default, it shows up as a DS4 Controller to Clone Hero. I recently went from PC to an M1 Mac and was disappointed when I could not pair my Wii Guitars with the game. Thought I should tell someone since this helped me heaps. ![]() The Raphnet adapter is the only adapter confirmed to work with Wiitars. The Elecom Wii Classic Controller adapter does not work, same for the Mayflash. Contact a subreddit moderator to verify your Reddit username. You need to be a verified charter in the CH Discord server. On the Xbox 360, RedOctane/Activision seems to be slightly more cross platform in their instruments. If you got into Guitar Hero from the onset, your Les Paul or original USB X-Plorer guitar is going to offer you a 'free' wired bass guitar for Rock Band or Rock Band 2. To bypass Google Drive's download quota, follow these steps: Create a folder on your Gdrive -> Select the file you need -> Create a shortcut -> Place it in the folder -> Download the folderīridge, a program for downloading charts directly to your computer The matrix below shows compatibility with Microsofts Xbox 360 game console. Spreadsheet with custom songs and setlists: Xbox 360 Guitar Hero World Tour - Stand Alone Drums (Renewed) by Amazon Renewed. Impovements and other changes this drum kit has over the Guitar Hero World Tour drum kit. Here you can post questions, videos and images etc. NEW Guitar Hero DRUM FOOT PEDAL Wii XBox 360 PS3 PS2 band world tour 4 5 bass. The Guitar Hero 5 drum kit is an updated version of the Guitar Hero World Tour drum kit, bundled in Guitar Hero 5, Band Hero, and the super bundle of Guitar Hero: Warriors of Rock. You can also check out our hands-on impressions of the game here.Clone Hero is a better made replica of the famous Guitar hero game. Recently, we were able to talk to design manager Pete O'Donnell, and you can read the interview here. Guitar Hero Live launches on October 20 for PlayStation 4, PlayStation 3, Xbox One, Xbox 360, Wii U, and mobile devices. The developer also hasn't said which microphones will be usable in the game, although the wording in the video suggests that any microphone compatible with your device will work. There's no word yet on if you can sing in the game's first-person "campaign" mode, called Guitar Hero Live. In the video, it appears that the singer and guitarist are playing in Guitar Hero TV, the game's on-demand music service. The developer also hasn't said anything about which Guitar Hero Live modes will support singing. The video shows only two-person multiplayer. It's unclear, however, whether you can play with two other people locally. If the game doesnt detect the controller the make sure that in device manager the dongle driver is set as a Xbox 360 Controller (or Peripheral I forgot the exact language). ![]() Vocals will be scored individually, as well, meaning that this adds more support for multiplayer, with someone playing guitar and someone singing. You can use any guitar hero live controller with a Guitar hero live Xbox 360 dongle. The matrix below shows compatibility with Microsoft's Xbox 360 game console. By clicking 'enter', you agree to GameSpot's ![]() ![]() ![]() You'll have to add that back to your fallout4custom.ini :( r/falloutlore - In depth discussion for everything lore relatedĬBBE requires these lines in your Fallout4Custom.ini to run: r/classicfallout - For the early Fallout games New Vegas Nexus - For all your New Vegas modding needsįallout 3 Nexus - For all your Fallout 3 modding needsįallout 4 Nexus - For all your Fallout 4 modding needs GECK WIKI - Wiki for the GECK mod making tool Just kidding, that would be a terrible story Please use spoiler tags for MAJOR game events. Please use tags in your post titles for what game, and what you want to discuss! Each post MUST have a tag for which game you are posting about.ĮXAMPLE : New Vegas Fiend Companion ![]() All others will be removed.Ĭomplete Bug Fix Guide for all Fallout Games Posts promoting a released mod must link to the MOD, not a videoĪll request posts must be in the weekly sticky thread (Wednesdays). Support posts without load orders (Not mod list) will be removed.ĭo not post the same mod/video more than once, with the exception of major updates. This includes posting mods that were removed / taken down. One word or vague titles will be removed.ĭo not post images / video unless you list the mods you use in the description / commentsĭon't promote Piracy. Request Wednesday - All Requests must go hereįILTER BY GAME Fallout 4 Fallout NV Fallout 3 Fallout 1, 2, Tactics Fallout 76Ĭlick here for a detailed version of our rules with clarificationĬomments not adding to discussion / flaming, will be removed.Got a mod to share? Want to talk about Modding? Need help? Whatever it is, you can do it here! Welcome to /r/falloutmods, Your one stop for Modding EVERYTHING Fallout. Complete Fix guide for all Fallout Games. ![]() ![]() It worth mentioning that the app constantly autosave each of your strokes to minimise any potential progress loss. There are some occasional crash here and there, but from my experiences it is only a minor nuisance and does not effect your progress. Sometimes it is buttery smooth, but other time it got its fair share of noticeable lagginess. There are cons of course but for me it is primarily the performance. I do not think I will able to return on using GN4 or even any other note taking app. The double tap to undo and triple tap to redo is a god send. Full disclosure, I start off with GN 4 and was given the free early upgrade pack to GN5 for the existing GN4 users.īelieve me when I said the features on GN4 felt very archaic now compare to GN5. I have been using GN for almost an entirety of my studies in an engineering courses and the app have help me a lot. It also provide a lot of useful tools and features for your notes taking needs. For what it worth, the app streamline the experience of notes writing on Ipad and makes it easier to sort through your notes. Goodnotes 5 takes what is good about Goodnotes 4 and make it even greater. ■ Import documents by emailing them to your custom Goodnotes email.įor the price of one paper notebook, get unlimited digital notebooks that are backed up, synced across your devices, and searchable for an entire year. ■ Send a link to your notebooks to work on the same notes directly, perfect for asynchronous work or collaborative brainstorming. ■ Export your notes to email, print, or share them anywhere as PDFs. ■ Use Laser Pointer on your Mac to guide your audience’s attention during your presentation. ■ Present your notes, slides, and content directly from Goodnotes when you connect your device via AirPlay or HDMI to an external screen. ■ Add, create, or import your stickers, stamps, washi tapes, images, and more to reuse again and again.įor professionals: Increase productivity at work ■ Customize the size and color of your paper templates to create the template you want. ■ Use AI to summarize, shorten, change the tone of your words, and otherwise perfect your typed text.įor planners: Let your creativity flow and create notes you can’t stop looking at ■ Study and practice straight from your notes with Study Sets - flashcards built on active recall and spaced repetition. ■ Search and instantly find any of your notes from any of your classes. ■ Record audio notes that are magically synced to the moment you write, perfect for lectures or presentations. ■ Edit your writing by resizing it, changing the color of your text, or moving it to another spot on the page. ■ Backup all your notes to Google Drive, Dropbox, or OneDrive and use iCloud to sync across iPad, iPhone, and Mac so your notes are always safe. PDF tables of contents are automatically imported otherwise create custom outlines yourself. ■ Create digital notebooks with customizable paper templates, including Blank Paper, Ruled Paper, Cornell Paper, Checklists, Planners, and more. ![]() ■ Combine both handwriting and typed text on one page, alongside images, stickers, diagrams and doodles. ![]() ![]() Unlimited notebooks for the price of one physical one. Either way, your notes are safe!*ĭigital notebooks. *Existing Goodnotes users can continue to use Goodnotes 5 indefinitely or upgrade to Goodnotes 6. Replace your paper notebooks and reimagine digital note-taking with Goodnotes. ![]() ![]() Her rescue, says Sergeant Zaglifa, was an unexpected reward for what he calls the "physically and emotionally draining" work of capturing child predators. Working with other agents, he traced Mancuso's Internet address to a location near Pittsburgh, where he was later arrested.ĭuring their investigation, police officials had no way of knowing that the little girl in the photographs was Mancuso's adopted daughter. Sergeant Zaglifa says his instinct told him this man was an absolute danger to children. Posing as a pedophile, Chicago area police officer Mike Zaglifa discovered Mancuso in an online chat room. Back in the states, Masha expected a nice American home with a bedroom all her own. No phone calls were made to his ex-wife or to his biological daughter. What she didn't know was the adoption agency failed to properly check her new father's background. But nothing could have been farther from the truth. Mancuso seemed like her knight in shining armor. He visited Masha several times at the orphanage, took her to nice dinners, and bought her candy. After months of waiting, Mancuso traveled to Russia to meet his new daughter. He contacted a New Jersey adoption agency requesting information on 5-year-old Caucasian girls, and chose Masha from a videotape. Meanwhile, 41-year-old Matthew Mancuso, a divorced father in Pennsylvania, was looking for a little girl to adopt. ![]() Soon after recovering from her traumatic ordeal, Masha was sent to an orphanage where she prayed that a good family would come to rescue her. Her own mother tried to kill her when she was only 4 years old by stabbing her in the back of the neck with a kitchen knife. She was born in southern Russia to an alcoholic mother and a father she never knew. At 13 years old, Masha has already survived the unthinkable. ![]() ![]() Likewise, chaperone downregulation or genetic aberration can cause diseases, such as mutation in the NEF co-chaperone BAG3 that leads to myopathy 24. ![]() For example, overexpression of the folding enzyme FKBP51 in a tau transgenic mouse model resulted in accumulation of tau and its toxic oligomers 21. ![]() Whereas chaperone overexpression typically improves the folding capacity of the chaperone system, overexpression of specific chaperones was shown to disrupt folding 19, 20, 21, 22, 23. However, the system also has limitations. The versatility and robustness of the chaperone system manifests in stress conditions, which lead to extensive upregulation of some chaperones. ![]() Likewise, co-chaperones containing the TPR domain, such as Hop, interact with both HSP70 and HSP90, thereby targeting substrates for either folding or degradation, respectively 18. For example, the same HSP70 chaperone can interact with different HSP40 co-chaperones, altering its substrate specificity 13. Most chaperones interact with multiple co-chaperones, and co-chaperones can interact with multiple chaperones, thereby modifying their function or the fate of their substrates. The chaperone system is highly versatile. Folding enzymes that catalyze folding-accelerating reactions, such as peptidyl prolyl cis– trans isomerization or protein disulfide isomerization 16, 17, are also considered as chaperones. Families of co-chaperones modulate the activity of main chaperones by regulating their ATPase cycle or the recognition, binding, or release of chaperone substrates, and include HSP10 9, HSP40 (DNAJ) 13, nuclear exchange factors (NEFs) 14, and co-HSP90 15. Families composing the main chaperone machinery, which modulate protein structure without participating in the final protein complex, include prefoldin 7, the small heat shock proteins (sHSP) 8, and the main ATP-hydrolyzing chaperones, HSP60 9, HSP70 10, HSP90 11, and HSP100 12. In human cell lines, for example, they were shown to compose ~10% of the total proteome mass 6.Ĭhaperones have been grouped into families based on their molecular mass, common domains, protein structure similarity, and common function 1. In accordance with their fundamental roles, chaperones are abundant proteins. Across species, they promote de novo protein folding and protein maturation 1, protein translocation 2, protein-complexes assembly and disassembly 3, protein disaggregation and refolding 4, and protein degradation 5. Similar content being viewed by othersĬhaperones are highly conserved molecular machines that control cellular protein homeostasis (proteostasis). ![]() In this work, we expand the known functional organization of de novo versus stress-inducible eukaryotic chaperones into a layered core-variable architecture in multi-cellular organisms. Analysis of human organ development and aging brain transcriptomes reveals that these functional networks are established in development and decline with age. Together with variable chaperones, they form tissue-specific functional networks. Core chaperones are significantly more abundant across tissues and more important for cell survival than variable chaperones. We demonstrate via a proteomic analysis that the muscle-specific signature is functional and conserved. Through computational analyses of large-scale tissue transcriptomes, we unveil that the chaperone system is composed of core elements that are uniformly expressed across tissues, and variable elements that are differentially expressed to fit with tissue-specific requirements. Yet, the organization of the chaperone system across physiological human tissues has received little attention. The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. ![]() ![]() I guess I'm beating a dead horse, but as somebody who uses mods, I'd like to give my two cents.įirst, I think I can say that I am an "honest" modder. Even though I've modded my game I still hate the people who jump into others games and ruin it for them. It's not to go into other peoples games and ruin the fun for them I mean most of the time I spent playing last night in another persons game was done refueling and repairing all there vehicles, then we killed the last two plague hearts I gave him about 20 or so med packs and left. Now if I jump into a game and there's stuck or something like that say almost dead sorta stuck in the middle of nowhere then yea I'll help the person get out of the problem by using My OP weapon but mainly I use that for MY playthrough because that's why I modded the game. I play with modded weapons but I dont do anything like that I like taking a weapon that's not suppose to have a scope and putting a scope on it or increasing the magazine size stuff like that and if I'm jumping into someone else's game I stick with them and play normally yes my weapons are stronger than normal but I dont oneshot plague hearts or stuff like that. Maybe I’m just whining about something that isn’t actually that big of a deal, but on a personal opinion it’s ruining the experience that an apocalypse game should have. ![]() I’m very much so reminded of the old Borderlands days where everyone and their grandmother had a modded gun that 1 shotted everything including Crawmerax. ![]() UL really needs to put their foot down about modding because it’s legitimately going to push some players away from this game. Modding has become even more of a problem than ever now since people are finding ways to kill your survivors and crash your game with modded weapons. However, for most people (who want to earn it) having these items given to you and / or killing every plague heart defeats the purpose of the game. Every single game I join the host either has an entirely modded survivor (which usually don’t even have the correct voice files, I’ll see a male model with a female voice) or a weapon that has a capacity of over 1,000 rounds.Īgain, I’m sure some people love this as let’s be honest, nightmare mode can be bullshit at times. However, at this point I’ve just stopped helping people. Now, I usually join other people’s games in order to assist them with tasks, or pass out weapons / goods that I have stockpiled on my current main Nightmare mode community. Having someone annihilate just about all of your objectives before you even get there is extremely stale and boring. ![]() The entire point of the game is to build up your community and survive. I’m sure some people would love for that to happen to them, but for me it just takes the fun out. Now, this wouldn’t be so bad if it weren’t for the fact that it is every single game that you join at least one person has either a modded survivor or weapon.Īs of recently I have started a new Nightmare mode community (I already have every achievement so I’m experimenting at this point) and within 30 minutes someone had entirely wiped out every single plague heart in my game, with a modded grenade launcher. State of Decay 2, at this point, is currently completely overran by modders. ![]() ![]() ![]() The advantage of lossless compression is that the compressed data is identical to the original file. The longer the file, the more drastic the difference is. "How much wood would a woodchuck chuck if a woodchuck could chuck wood?" When you compare these lines, you can see that the second one is shorter. The phrase could then be compressed to this line: How much (1) would a (1)(2) (2) if a (1)(2) could (2) (1)? They assign redundant phrases to shorter codes that replace them.įor example, let's use the tongue twister: "How much wood would a woodchuck chuck if a woodchuck could chuck wood?" Lossless compression achieves compression by removing redundancy from a string of bits via the use of various algorithms. Lossless compression is easier to understand as it is relatively simple. They compress files differently and have their specific purposes. To truly comprehend how file or folder compression works, you must understand the two types of file compression: lossless and lossy. How does file and folder compression work? WinZip is better than Windows' built-in feature because you get many more features.įor example, you can encrypt, password-protect, and convert your archived files using WinZip, and you also get access to other tools like Advanced Backup, Duplicate Cleanup, and more. You could also share them directly via email, social media, and other platforms.Īnd just like that, you've compressed a file through WinZip.Click Save as… and choose where you want your zip saved.In the Files pane to the left, select which files you want to be compressed.Here's how you can compress a file on WinZip. ![]() It has several features relevant to file compression. WinZip is a file management and compression software. It's also easy to decompress the file-just right-click the compressed folder and select Extract all….Īnd just like that, you've compressed and decompressed your files on Windows.Īnother alternative to file compression is WinZip on Windows. You can then delete the old document to save space. To compress a folder, right-click the folder and select Compress to ZIP file.Ī compressed copy of the file should appear in the exact location. If you want to compress several files on Windows, you can gather them into a single folder and compress the folder itself. While the previous versions of Windows might have required several steps to compress a file, the latest version-Windows 11-only requires a few steps. How do I compress files and folders on Windows? ![]() ![]() Listing Information presented by local MLS brokerage: Zillow, Inc., Designated REALTOR®- Chris Long - (480) 907-1010 All rights reserved.Īll information should be verified by the recipient and none is guaranteed as accurate by ARMLS The broker providing these data believes them to be correct, but advises interested parties to confirm them before relying on them in a purchase decision.Ĭopyright 2024 GAMLS. All real estate listings are marked with the GAMLS Broker Reciprocity thumbnail logo and detailed information about them includes the name of the listing brokers. The data relating to real estate for sale on this web site comes in part from the Broker Reciprocity Program of GAMLS. (/info/mls-disclaimers/#mls_28)īy searching Northstar MLS listings you agree to the () Some IDX listings have been excluded from this website. Properties may or may not be listed by the office/agent presenting the information. All information should be independently reviewed and verified for accuracy. Supplied Open House Information is subject to change without notice. All data is obtained from various sources and may not have been verified by broker or MLS GRID. (/info/mls-disclaimers/#mls_27)īased on information submitted to the MLS GRID as of 18:17:48 PST. Information being provided is for consumers’ personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Data maintained by the Board or ACTRIS may not reflect all real estate activity in the market. All data is provided “AS IS” and with all faults. Neither the Board nor ACTRIS guarantees or is in any way responsible for its accuracy. Listing Information presented by local MLS brokerage: Zillow, Inc - (407) 904-3511īased on information from Unlock MLS (alternatively, from ACTRIS) for the period through 18:19:42 PST. Information is deemed reliable but not guaranteed. IDX information is provided exclusively for personal, non-commercial use, and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. The listing broker’s offer of compensation is made only to participants of the MLS where the listing is filed. ![]() Properties may or may not be listed by the office/agent presenting the information ![]() All data, including all measurements and calculations of area, is obtained from various sources and has not been, and will not be, verified by broker or MLS. as of 18:20:13 PST and /or other sources. ![]() The viewer should independently verify the listed data prior to making any decisions based on such information by personal inspection and/or contacting a real estate professional.īased on information from California Regional Multiple Listing Service, Inc. ![]() All listing data, including but not limited to square footage and lot size is believed to be accurate, but the listing Agent, listing Broker and CRMLS and its affiliates do not warrant or guarantee such accuracy. Information provided is for viewer's personal, non-commercial use and may not be used for any purpose other than to identify prospective properties the viewer may be interested in purchasing. ("CRMLS") and is protected by all applicable copyright laws. The multiple listing data appearing on this website, or contained in reports produced therefrom, is owned and copyrighted by California Regional Multiple Listing Service, Inc. ![]() |
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